The operation of our cooling technologies needs to be digitalized to enable real-time monitoring and optimization, a feature for the next-generation DCs. Inter-domain optimization and optimized operating guidelines are only possible with digitalization. The former pushes the boundary for the optimized performance of the integrated hybrid cooling technologies while the latter enables widespread adoption of known good practices for greener DC operations. The aforementioned objectives can be achieved through the synergistic integration of different innovative cooling technologies.